Cornelia de Lange syndrome (CdLS) is a disorder that results in several physical and developmental abnormalities. It is said to occur in 1 in 10,000 to 1 in 30,000 live births and is found equally in males and females. Cornelia de Lange syndrome is characterized by slow growth and intellectual disability that is usually severe to profound. The facial differences include thin, arched eyebrows; long eyelashes; low-set ears; small, widely spaced teeth; and a small, upturned nose. Many affected individuals also have behavior problems similar to autism.
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